Clozapine may control suicidal command hallucinations. Lithium often reduces suicidality in patients with Bipolar Disorder. Antidepressants may reduce suicidality in elderly patients with Major Depressive Disorder. NMDA-receptor antagonists, like ketamine, may reduce suicidality in others. Response to any one treatment is not trans-nosological across all suicidality disorder phenotypes.
Sheehan & Giddens created a phenotypic classification system for suicidality episodes and suicidality disorders. This phenotypic classification may help clinicians better select a treatment based on the patient’s phenotype. The suicidality disorders classification provides a system to gather phenotypic-specific information on each suicidality disorder. A good phenotypic classification may provide better predictive models of treatment response for those at risk of dying by suicide.
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