Sheehan Irritability Scale (SIS)

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About the SIS
License Agreements for Use of the SIS
Training for the SIS
Translations and Linguistic Validation of the SIS
How to Cite the SIS


About the SIS

The Sheehan Irritability Scale (SIS), a seven-item self-report rating scale. It was developed to measure the frequency, severity and impairment associated with irritability. It is designed to be a sensitive outcome measure, sensitive to change and to treatment effects in patients with psychiatric and neurological disorders.  The SIS consists of seven items that assess symptoms of irritability, frustration, edginess/impatience, moodiness, anger with self, anger with others and temper during the previous week. Each item is assessed on an 11-point numeric rating scale ranging from 0 (not at all) to 10 (extremely).  The SIS total score is calculated by summing of the scores for each of the seven individual items and ranges from 0 to 70.  A higher score indicates greater symptomatology.  There is an additional assessment question of how frequently irritability interfered with ability to function at work/school, socially or with family members, but is not part of the total score. The SIS can be used as a baseline assessment and at any time interval.

Validation of SIS

The objective of the SIS validation study (Khan et al) was to examine the psychometric properties (i.e. reliability, validity) of the SIS in patients in Major Depressive Disorder (MDD). This study evaluated reliability, validity (construct and known groups) and responsiveness of the SIS.  It examined the psychometric properties of two modes of administration – the self-administered (US sample) and clinician-administered through patient interview (non-US sample) – with the goal of evaluating equivalence between the two. These psychometric characteristics were evaluated through a secondary analysis of clinical trial data.  The Khan et al study reported that “the SIS has excellent reliability, acceptable validity, and good responsiveness, making the SIS appropriate for use in clinical research and practice”.  Another report by Mannix et al supported the content validity of the Sheehan Irritability Scale.

For any scientific questions relating to the SIS, contact David V Sheehan MD MBA directly by email at: davidvsheehan@gmail.com

To view a copy of the SIS (click here)

To purchase and download a copy of the SIS (click here)


License Agreements for Use of the SIS

To license any version of the SIS for Use in a Study or for a Healthcare System:

  • To License the Paper / PDF Version for Use in a Research Study with Grants >$50,000 or for a Pharmaceutical Company – There is a charge of $1 per single administration (not per patient enrolled). The amount is payable in full before study initiation.  (click here to download this license agreement)
  • To License the Paper / PDF Version for Use in a Research Study with Grants <$50,000 – The SIS is available free of charge to undergraduate and graduate students and for academic colleagues for educational use and for use in a small study with less than $50,000 funding as long as it is properly cited and proper copyright attribution is given on any study documents.  (click here to download this license agreement)
  • To License the Paper / PDF Version for Use in a Healthcare System – There is a charge of $1 per single administration (not per patient). The amount is payable in full before use.  (click here to download this license agreement)
  • To LicenseComputerized / Electronic / Mobile or Tablet App Version for Use – contact akozsuch@nviewhealth.com

Training for the SIS

For information about training on the SIS, please contact: davidvsheehan@gmail.com


Translations and Linguistic Validation of the SIS

Mapi (http://www.mapigroup.com) is the official translation and linguistic validation service for all variants of the SIS.

MAPI Language Services is the exclusive coordinating center to ensure the production of consistent and conceptually equivalent translations of the SIS and to provide linguistic validation and certification of these translations and should be contacted directly for this purpose.  MAPI Language Services may charge its own usual fees for this work.

Marie-Sidonie Edieux

MAPI Research Trust

27 Rue de la Villette

69003 Lyon France

PROinformation@mapigroup.com

tel: +33 (0)4 72 13 66 67

fax: +33 (0)4 72 13 66 68/ :+33 (0)4 72 13 69 50


How to Cite the SIS

Use the following citations in referencing the SIS:

  1. Khan SA, Revicki DA, Hassan M, Locklear JC, Friedman LA, Mannix S, Tummala R, Eriksson H and Sheehan DV. Assessing the reliability and validity of the Sheehan Irritability Scale in patients with major depressive disorder. J Clin Psychiatry 2016;77(8):1080-1086. DOI: https://doi.org/10.4088/JCP.14m09719
  2. Mannix S; Hassan M, Tummala R, Locklear JC, Revicki DA, Khan S, Dunbar GC, Eriksson H, Sheehan, DV. Content validity of the Sheehan Irritability Scale in patients with major depressive disorder. International Clinical Psychopharmacology. 2016.  DOI: https://doi.org/10.1097/YIC.0000000000000113